[PDF][PDF] Cardiac macrophages and emerging roles for their metabolism after myocardial infarction
EB Thorp - Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Interest in cardioimmunology has reached new heights as the experimental cardiology field
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Highlights•Itaconate modulates metabolic pathways relevant to tumor growth.•Itaconate
influences immune cell function and TME.•Itaconate inhibits TET methylcytosine …
influences immune cell function and TME.•Itaconate inhibits TET methylcytosine …
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex
(OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial …
(OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial …
[HTML][HTML] Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2
A Heinz, Y Nonnenmacher, A Henne, MA Khalil… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Macrophages undergo extensive metabolic reprogramming during classical pro-
inflammatory polarization (M1-like). The accumulation of itaconate has been recognized as …
inflammatory polarization (M1-like). The accumulation of itaconate has been recognized as …
Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis
Background Long COVID is a debilitating chronic condition that has affected over 100
million people globally. It is characterized by a diverse array of symptoms, including fatigue …
million people globally. It is characterized by a diverse array of symptoms, including fatigue …
Immunometabolism at the heart of cardiovascular disease
M DeBerge, R Chaudhary, S Schroth… - Basic to Translational …, 2023 - jacc.org
Immune cell function among the myocardium, now more than ever, is appreciated to
regulate cardiac function and pathophysiology. This is the case for both innate immunity …
regulate cardiac function and pathophysiology. This is the case for both innate immunity …
Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls
Tumor-associated macrophages (TAMs) constitute an important part of the tumor
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …
[HTML][HTML] 2-hydroxyglutarate rides the cancer-immunity cycle
Highlights•Cancer cell-derived D-and L-2HG regulate antitumor immunity.•Both 2HG
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …
Oncometabolite 2-hydroxyglutarate regulates anti-tumor immunity
M Cai, J Zhao, Q Ding, J Wei - Heliyon, 2024 - cell.com
Abstract" Oncometabolite" 2-hydroxyglutarate (2-HG) is an aberrant metabolite found in
tumor cells, exerting a pivotal influence on tumor progression. Recent studies have unveiled …
tumor cells, exerting a pivotal influence on tumor progression. Recent studies have unveiled …
[HTML][HTML] Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages
Immunometabolism has been unveiled in the last decade to play a major role in controlling
macrophage metabolism and inflammation. There has been a constant effort to understand …
macrophage metabolism and inflammation. There has been a constant effort to understand …