Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Small RNAs in epigenetic inheritance: from mechanisms to trait transmission
G Cecere - FEBS letters, 2021 - Wiley Online Library
Inherited information is transmitted to progeny primarily by the genome through the gametes.
However, in recent years, epigenetic inheritance has been demonstrated in several …
However, in recent years, epigenetic inheritance has been demonstrated in several …
Small RNAs and chromatin in the multigenerational epigenetic landscape of Caenorhabditis elegans
N Frolows, A Ashe - … Transactions of the Royal Society B, 2021 - royalsocietypublishing.org
For decades, it was thought that the only heritable information transmitted from one
individual to another was that encoded in the DNA sequence. However, it has become …
individual to another was that encoded in the DNA sequence. However, it has become …
[HTML][HTML] piRNAs coordinate poly (UG) tailing to prevent aberrant and perpetual gene silencing
A Shukla, R Perales, S Kennedy - Current Biology, 2021 - cell.com
Noncoding RNAs have emerged as mediators of transgenerational epigenetic inheritance
(TEI) in a number of organisms. A robust example of such RNA-directed TEI is the …
(TEI) in a number of organisms. A robust example of such RNA-directed TEI is the …
Hypoxia induces transgenerational epigenetic inheritance of small RNAs
Animals sense and adapt to decreased oxygen availability, but whether and how hypoxia
exposure in ancestors can elicit phenotypic consequences in normoxia-reared descendants …
exposure in ancestors can elicit phenotypic consequences in normoxia-reared descendants …
Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed
with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their …
with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their …
Mating can initiate stable RNA silencing that overcomes epigenetic recovery
S Devanapally, P Raman, M Chey, S Allgood… - Nature …, 2021 - nature.com
Stable epigenetic changes appear uncommon, suggesting that changes typically dissipate
or are repaired. Changes that stably alter gene expression across generations presumably …
or are repaired. Changes that stably alter gene expression across generations presumably …
[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways
U Seroussi, C Li, AE Sundby, TL Lee… - Seminars in Cell & …, 2022 - Elsevier
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
[HTML][HTML] Epigenetic dynamics during germline development: insights from Drosophila and C. elegans
RJ Gleason, X Chen - Current opinion in genetics & development, 2023 - Elsevier
Gametogenesis produces the only cell type within a metazoan that contributes both genetic
and epigenetic information to the offspring. Extensive epigenetic dynamics are required to …
and epigenetic information to the offspring. Extensive epigenetic dynamics are required to …
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that
use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one …
use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one …