Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Although cancer remains a devastating diagnosis, several decades of preclinical progress in
cancer biology and biotechnology have recently led to successful development of several …

The specificities of 65 compounds reported to be relatively specific inhibitors of protein
kinases have been profiled against a panel of 70–80 protein kinases. On the basis of this …

Small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. The prognosis of
SCLC patients is devastating and no biologically targeted therapeutics are active in this …

Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

Mitosis is commonly thought to be associated with reduced cap-dependent protein
translation. Here we show an alternative control mechanism for maintaining cap-dependent …

We elucidate the molecular mechanisms of two distinct activation strategies
(autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic …

The process of cell division or mitosis is highly complex and tightly regulated. During this
phase of the cell cycle two identical copies of DNA are completely separated by the …

Aurora kinases are a family of serine/threonine kinases that play a crucial role in cell
proliferation through the regulation of mitotic spindles. These kinases are the regulatory …

The correct assembly and timely disassembly of the mitotic spindle is crucial for the
propagation of the genome during cell division. Aurora kinases play a central role in …