Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …

The active form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is primarily
known as a key regulator of calcium and phosphate homeostasis. It exerts its biological …

Background Vitamin D has been suggested to prevent and improve the prognosis of several
cancers, including breast cancer. We have previously shown a U-shaped association …

Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate
pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an …

Vitamin D 3 is the precursor of 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), a pleiotropic
hormone that is a major regulator of the human genome. 1, 25 (OH) 2 D 3 modulates the …

Background: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a
wide variety of biological processes including regulation of cell proliferation and …

The nuclear receptor for 1α, 25-dihydroxycholecalciferol (1, 25D), the active form of vitamin
D, has anti-tumor actions in many tissues. The vitamin D receptor (VDR) is expressed in …

Background A higher vitamin D intake improves the prognosis of early stage breast cancer
(BC) patients. We hypothesized that vitamin D intake should refer to vitamin D receptor …

Abstract Vitamin D Receptor (VDR), a nuclear steroid receptor, is a transcription factor with a
primary physiologic role in calcium metabolism. It has also a physiologic role in breast …

Breast cancer (BC) is the most frequent malignant tumor in women in Europe and North
America, and the use of aromatase inhibitors (AIs) is recommended in women affected by …