Binding free energy calculations based on molecular simulations provide predicted affinities
for biomolecular complexes. These calculations begin with a detailed description of a …

The 2H-1, 4-benzoxazin-3-(4H)-one (1) and 3, 4-dihydro-2H-1, 4-benzoxazine (2) scaffolds
have been studied intensively as important heterocyclic systems for building natural 1, 2 and …

Creating sequential one-pot combinations of multi-component reactions (MCRs) and multi-
catalysis cascade (MCC) reactions is a challenging task that has already emerged as a new …

Many populations suffer from thrombotic disorders such as stroke, myocardial infarction,
unstable angina and thromboembolic disease. Thrombus is one of the major threatening …

Multicatalysis cascade (MCC) process for the synthesis of highly substituted chiral building
blocks (2-alkyl-CH-acids, 2-alkylcyclohexane-1, 3-diones, 2-alkylcyclopentane-1, 3-diones …

The platelet integrin GPIIb/IIIa plays an essential role in thrombus formation through
interactions with adhesive ligands and has emerged as a primary target for the development …

3, 4-Dihydro-2 H-1, 4-benzoxazine derivatives possessing both thrombin inhibitory and
glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonistic activities were obtained by combining …

A multipathway strategy was used to evaluate the in vitro and in vivo antithrombotic effects of
a new synthetic family of sulfated small molecules. Polysulfated xanthonosides showed …

A carboxylic ester group was introduced to three series of isoindolinedione substituted
benzoxazinone derivatives. Some of these analogues exhibited good herbicidal activities …

A new series of persulfated compounds was synthesized and assayed for in vitro
anticoagulant and antiplatelet activities, which may be useful in the treatment of both venous …