Background and Objectives: The tumor microenvironment has been widely implicated in
tumorigenesis because it harbors tumor cells that interact with surrounding cells through the …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

JCI - Differential roles of regulatory T cells in acute respiratory infections Go to JCI Insight About
Editors Consulting Editors For authors Publication ethics Alerts Advertising Job board Subscribe …

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

The fate of developing T cells is specified by the interaction of their antigen receptors with
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Cancers are not just masses of malignant cells but complex 'rogue'organs, to which many
other cells are recruited and can be corrupted by the transformed cells. Interactions between …