The microbial population residing within the human gut represents one of the most densely
populated microbial niche in the human body with growing evidence showing it playing a …

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the
neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread …

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

A growing body of researches support a role for dysfunction of serotoninergic,
noradrenergic, and dopaminergic systems in the neurobiological processes involved in …

Depression is one of the most common psychological diseases with significant potential
morbidity and mortality. Although the underlying pathophysiology of depression has not …

There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin
(5HT) neurotransmitter systems in depression and anxiety disorders. The majority of …

Objective: The present paper reviews the evidence that depression is a risk factor for the
development and progression of coronary artery disease (CAD). Methods: MEDLINE …

The 1950s saw the clinical introduction of the first two specifically antidepressant drugs:
iproniazid, a monoamine-oxidase inhibitor that had been used in the treatment of …

Serotonin and Depression: A Disconnect between the Advertisements and the Scientific
Literature | PLOS Medicine Skip to main content Advertisement PLOS Medicine Browse …

This article critically reviews the evidence that exercise is effective in treating depression in
adults. Depression is recognised as a mood state, clinical syndrome and psychiatric …