Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

Alzheimer´ s disease (AD) and related forms of dementia are increasingly affecting the aging
population throughout the world, at an alarming rate. The World Alzheimer´ s Report …

Alzheimer disease (AD) is one of the most common neurodegenerative diseases, affecting
middle-aged and elderly individuals worldwide. AD pathophysiology involves the …

Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …

The senescence-accelerated mouse prone-8 (SAMP8) model has been considered as a
good model for aged-related cognitive decline and Alzheimer's disease (AD). Since …

It has been established that ageing is the major risk factor for cognitive deficiency and it is
becoming increasingly evident that insulin resistance is another factor. Biological plausibility …

Environmental factors such as maternal high-fat diet (HFD) intake can increase the risk of
age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link …

α-Adrenergic receptors are crucial regulators of vascular hemodynamics and essential
pharmacological targets for cardiovascular diseases. With aging, there is an increase in …