Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Importance Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease
of the central nervous system characterized by inflammatory demyelination with axonal …

Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of
the central nervous system, and the leading cause of nontraumatic neurological disability in …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. NRF2 induces expression of detoxification and antioxidant …

Importance To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …

The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …

Importance Treatment strategies for relapsing-remitting multiple sclerosis (RRMS) vary
markedly between Denmark and Sweden. The difference in the association of these national …