Bacterially induced bone destruction: mechanisms and misconceptions

SP Nair, S Meghji, M Wilson, K Reddi… - Infection and …, 1996 - Am Soc Microbiol
Normal bone remodelling requires the coordinated regulation of the genesis and activity of
osteoblast and osteoclast lineages. Any interference with these integrated cellular systems …

Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy

FW Booth, MV Chakravarthy… - Journal of applied …, 2002 - journals.physiology.org
A hypothesis is presented based on a coalescence of anthropological estimations of Homo
sapiens' phenotypes in the Late Paleolithic era 10,000 years ago, with Darwinian natural …

Nitric oxide and bone

RJ Van'T Hof, SH Ralston - Immunology, 2001 - Wiley Online Library
Nitric oxide (NO) is a free radical which has important effects on bone cell function. The
endothelial isoform of nitric oxide synthase (eNOS) is widely expressed in bone on a …

Calcium metabolism and oxidative stress in bone fractures: role of antioxidants

SA Sheweita, KI Khoshhal - Current drug metabolism, 2007 - ingentaconnect.com
Calcium ion is an essential structural component of the skeleton. There is growing evidence
for the importance of nutrition in the maintenance of bones and joints health. Nutritional …

Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain

R Smalt, FT Mitchell, RL Howard… - American Journal of …, 1997 - journals.physiology.org
The nature of the stimulus sensed by bone cells during mechanical usage has not yet been
determined. Because nitric oxide (NO) and prostaglandin (PG) production appear to be …

Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase

KE Armour, KJ Armour, ME Gallagher… - …, 2001 - academic.oup.com
Nitric oxide (NO) is a pleiotropic signaling molecule that is produced by bone cells
constitutively and in response to diverse stimuli such as proinflammatory cytokines …

Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling

PN Colleran, MK Wilkerson… - Journal of applied …, 2000 - journals.physiology.org
Bone loss occurs as a consequence of exposure to microgravity. Using the hindlimb-
unloaded rat to model spaceflight, this study had as its purpose to determine whether …

Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast …

J Aguirre, L Buttery, M O'Shaughnessy, F Afzal… - The American journal of …, 2001 - Elsevier
Nitric oxide (NO) has been implicated in the local regulation of bone metabolism. However,
the contribution made by specific NO synthase (NOS) enzymes is unclear. Here we show …

Pulp–dentin tissue healing response: a discussion of current biomedical approaches

D Shah, T Lynd, D Ho, J Chen, J Vines… - Journal of clinical …, 2020 - mdpi.com
Dental pulp tissue exposed to mechanical trauma or cariogenic process results in root canal
and/or periapical infections, and conventionally treated with root canal procedures. The …

Silicon nitride: a bioceramic with a gift

G Pezzotti - ACS applied materials & interfaces, 2019 - ACS Publications
In the closing decades of the 20th century, silicon nitride (Si3N4) was extensively developed
for high-temperature gas turbine applications. Technologists attempted to take advantage of …