All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

The neural crest is a stem/progenitor cell population that contributes to a wide variety of
derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and …

Waardenburg syndrome (WS) is characterized by the association of pigmentation
abnormalities, including depigmented patches of the skin and hair, vivid blue eyes or …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

The molecular biology of metastatic potential in melanoma has been studied many times
previously and changes in the expression of many genes have been linked to metastatic …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells
acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic
of Hirschsprung's disease with reduced pigment cell number, although the cell biological …