Active cell death, in its many forms, is a fundamental biological process. Studies over the
past several decades have explored the functions and consequences of cellular demise and …

The major mode of apoptosis in vertebrates is the mitochondrial pathway. This pathway of
cell death is engaged by a vast array of cell stresses, including deprivation of growth factors …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Abstract The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but
genomically poorly explored phyla, the Mollusca. Here we report the sequencing and …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

Although required for life, paradoxically, mitochondria are often essential for initiating
apoptotic cell death. Mitochondria regulate caspase activation and cell death through an …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

Intrinsic apoptosis, the response to intracellular cell death stimuli, is regulated by the
interplay of the B-cell lymphoma 2 (Bcl-2) family and their membrane interactions. Bcl-2 …

Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective
mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction …