The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant
medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a …

A significant interaction between kidneys and lungs has been shown in physiological and
pathological conditions. The two organs can both be targets of the same systemic disease …

Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal
transplantation. In our previous study, we found that epithelial–mesenchymal transition …

Activin B, a homodimer of inhibin beta b (INHBB), is a multifunctional cytokine belonging to
the transforming growth factor-β (TGF-β) family. However, the molecular functions and …

Radiation-induced liver fibrosis (RILF) is a serious complication of the radiotherapy of liver
cancer, which lacks effective prevention and treatment measures. Kinsenoside (KD) is a …

ABSTRACT SH3PXD2A/TKS5 (SH3 and PX domains 2A) is a scaffold protein that promotes
invadopodia formation and regulates cell migration; therefore, the overexpression of …

Cystic fibrosis (CF) is a disease that most commonly affects the lungs and is characterized
by mucus retention and a continuous cycle of bacterial infection and inflammation. Current …

To add new molecular and pathogenetic insights into the biological machinery associated to
kidney allograft fibrosis is a major research target in nephrology and organ transplant …

Rapamycin (sirolimus) is a mTOR kinase inhibitor and is widely used as an
immunosuppressive drug to prevent graft rejection in organ transplantation currently …

The mammalian target of rapamycin inhibitors (mTOR-Is, Sirolimus, and Everolimus) are
immunosuppressive drugs widely employed in kidney transplantation. Their main …