Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies
S Vakili-Samiani, AT Jalil, WK Abdelbasset… - DNA repair, 2021 - Elsevier
Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …
[HTML][HTML] The notch ligand JAGGED1 as a target for anti-tumor therapy
D Li, M Masiero, AH Banham, AL Harris - Frontiers in oncology, 2014 - frontiersin.org
The Notch pathway is increasingly attracting attention as a source of therapeutic targets for
cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer …
cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer …
[HTML][HTML] Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
CS Park, H Yoshihara, Q Gao, C Qu, I Iacobucci… - Cell reports, 2023 - cell.com
The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …
[HTML][HTML] Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges
MW Lee, S Ryu, DS Kim, JW Lee, KW Sung, HH Koo… - Leukemia, 2019 - nature.com
Mesenchymal stem cells (MSCs) are known for being multi-potent. However, they also
possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer …
possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer …
[HTML][HTML] Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting
F Chiarini, A Lonetti, C Evangelisti, F Buontempo… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The bone marrow (BM) microenvironment regulates the properties of healthy hematopoietic
stem cells (HSCs) localized in specific niches. Two distinct microenvironmental niches have …
stem cells (HSCs) localized in specific niches. Two distinct microenvironmental niches have …
Vascular smooth muscle cells initiate proliferation of mesenchymal stem cells by mitochondrial transfer via tunneling nanotubes
KC Vallabhaneni, H Haller, I Dumler - Stem cells and development, 2012 - liebertpub.com
Multipotent mesenchymal stem cells (MSCs) are promising candidates for regenerative cell-
based therapy. The mechanisms underlying MSC differentiation and other functions relevant …
based therapy. The mechanisms underlying MSC differentiation and other functions relevant …
The immunomodulatory effects of mesenchymal stem cell polarization within the tumor microenvironment niche
CM Rivera-Cruz, JJ Shearer… - Stem cells …, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy, particularly for
their antitumor effects. This cell population can be isolated from multiple tissue sources and …
their antitumor effects. This cell population can be isolated from multiple tissue sources and …
[HTML][HTML] The role of notch and wnt signaling in MSC communication in normal and leukemic bone marrow niche
P Takam Kamga, R Bazzoni, G Dal Collo… - Frontiers in cell and …, 2021 - frontiersin.org
Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …
involved in developmental processes, such as hematopoiesis. Even though data from …
[HTML][HTML] Novel mechanism of inhibition of dendritic cells maturation by mesenchymal stem cells via interleukin-10 and the JAK1/STAT3 signaling pathway
W Liu, J Liu, J Wu, L Zhang, F Liu, L Yin, M Zhang… - PloS one, 2013 - journals.plos.org
Mesenchymal stem cells (MSCs) can suppress dendritic cells (DCs) maturation and function,
mediated by soluble factors, such as indoleamine 2, 3-dioxygenase (IDO), prostaglandin E2 …
mediated by soluble factors, such as indoleamine 2, 3-dioxygenase (IDO), prostaglandin E2 …
[HTML][HTML] Extracellular vesicles mediate mesenchymal stromal cell-dependent regulation of B cell PI3K-AKT signaling pathway and actin cytoskeleton
Mesenchymal stromal cells (MSCs) are adult, multipotent cells of mesodermal origin
representing the progenitors of all stromal tissues. MSCs possess significant and broad …
representing the progenitors of all stromal tissues. MSCs possess significant and broad …