Human respiratory virus infections lead to a spectrum of respiratory symptoms and disease
severity, contributing to substantial morbidity, mortality and economic losses worldwide, as …

Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step
in a future pandemic. Several factors that limit the transmission and replication of avian IAVs …

Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens,
influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to …

Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has been a global public health emergency since …

Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza
virus genome replication. While most influenza viruses cannot replicate in edited human …

Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …