Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …

The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …

▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

The random generation of antigen receptors in developing lymphocytes results in a
considerable risk of autoimmunity. Regulatory T cells (Treg cells) act in a dominant, trans …

T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …

Abstract Development of immature T-cell precursors (thymocytes) to either the CD4 helper or
CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major …

Activation of extracellular-signal-regulated protein kinase (Erk) is central to growth-factor-
receptor-mediated signaling including that originating from the T cell antigen receptor. It …