Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia
V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
The burning furnace: Alteration in lipid metabolism in cancer-associated cachexia
Cancer cachexia can be defined as a complex metabolic syndrome characterized by weight
loss, anorexia, and emaciation due to the wasting of adipose tissue and skeletal muscle. In …
loss, anorexia, and emaciation due to the wasting of adipose tissue and skeletal muscle. In …
UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting
Cancer cachexia is a lethal metabolic syndrome featuring muscle wasting with preferential
loss of fast-twitching muscle mass through an undefined mechanism. Here, we show that …
loss of fast-twitching muscle mass through an undefined mechanism. Here, we show that …
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle
JB Ducharme, ZJ McKenna… - American Journal of …, 2022 - journals.physiology.org
Conditions characterized by muscle wasting such as cachexia and sarcopenia are
devastating at the individual level, and they place a profound burden on public health …
devastating at the individual level, and they place a profound burden on public health …
The dependency of autophagy and ubiquitin proteasome system during skeletal muscle atrophy
A Singh, J Phogat, A Yadav, R Dabur - Biophysical Reviews, 2021 - Springer
Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …
Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole
Background Cancer cachexia, characterized by muscle and fat tissue wasting, is a major
determinant of cancer‐related mortality without established treatment. Recent animal data …
determinant of cancer‐related mortality without established treatment. Recent animal data …
Cancer-induced muscle wasting requires p38β MAPK activation of p300
Cancer-associated cachexia, characterized by muscle wasting, is a lethal metabolic
syndrome without defined etiology or established treatment. We previously found that p300 …
syndrome without defined etiology or established treatment. We previously found that p300 …
Progressive skeletal muscle atrophy in muscular dystrophies: a role for toll-like receptor-signaling in disease pathogenesis
B De Paepe - International Journal of Molecular Sciences, 2020 - mdpi.com
Muscle atrophy is an active process controlled by specific transcriptional programs, in which
muscle mass is lost by increased protein degradation and/or decreased protein synthesis …
muscle mass is lost by increased protein degradation and/or decreased protein synthesis …
Pathological features of tissues and cell populations during cancer cachexia
D Di Girolamo, S Tajbakhsh - Cell Regeneration, 2022 - Springer
Cancers remain among the most devastating diseases in the human population in spite of
considerable advances in limiting their impact on lifespan and healthspan. The multifactorial …
considerable advances in limiting their impact on lifespan and healthspan. The multifactorial …
Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments
JB Ducharme, ZJ McKenna… - Journal of Applied …, 2024 - journals.physiology.org
Exercise in hypoxia increases immune responses compared with normoxic exercise, and
while Toll-like receptor 4 (TLR4) is implicated in these responses, its regulation remains …
while Toll-like receptor 4 (TLR4) is implicated in these responses, its regulation remains …