Background Haemoglobinopathies can reduce the risk of malaria syndromes. We aimed to
quantify the relation between different haemoglobin mutations and malaria protection to …

The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Genetic polymorphisms in blood donors may contribute to donor-specific differences in the
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …

Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …

Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …

Background: Development of alloantibodies against the foreign red blood cell (RBC)(
alloimmunization) is a well-known complication in thalassemia patients when performing …

Background The evolutionary pressure of endemic malaria and other erythrocytic pathogens
has shaped variation in genes encoding erythrocyte structural and functional proteins …

Over recent millennia, human populations have regularly reconstructed their subsistence
niches, changing both how they obtain food and the conditions in which they live. For …

Sickle cell disease (SCD) is a genetic disorder that poses a serious health threat in tropical
Africa, which the World Health Organization has declared a public health priority. Its …