Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective
Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …
liver problem for hepatologists owing to unregulated medication usage in medical practices …
Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …
biological agents, and medical products. These reactions can manifest as acute or chronic …
Flaxseed lignan alleviates the paracetamol-induced hepatotoxicity associated with regulation of gut microbiota and serum metabolome
Y Ren, Z Xu, Z Qiao, X Wang, C Yang - Nutrients, 2024 - mdpi.com
This study examined the protective effect of flaxseed lignans on liver damage caused by an
overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d …
overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d …
Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and …
Paracetamol is extensively consumed as an analgesic and antipyretic drug, but at a high
dose level, it leads to deleterious side effects, such as hepatic and nephrotoxicity. This …
dose level, it leads to deleterious side effects, such as hepatic and nephrotoxicity. This …
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal
GA Mohamed Kamel, E Harahsheh… - Molecular Biology Reports, 2022 - Springer
Background Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic
medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID …
medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID …
Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice
H Ma, S Chen, H Xiong, M Wang, W Hang, X Zhu… - Food & function, 2020 - pubs.rsc.org
The aim of this study is to probe a new function of astaxanthin (AST) from Haematococcus
pluvialis on chemotherapeutic drug induced liver injury in mice. Doxorubicin-induced liver …
pluvialis on chemotherapeutic drug induced liver injury in mice. Doxorubicin-induced liver …
Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase
RM Hussein, MA Kandeil, NA Mohammed… - Journal of Liposome …, 2022 - Taylor & Francis
Curcumin (Cur) is a natural compound that exhibited therapeutic effects against various liver
injuries however Cur showed poor water solubility and bioavailability. This study aimed to …
injuries however Cur showed poor water solubility and bioavailability. This study aimed to …
The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis
Morin is a flavonoid and broadly found in white berry and cranberry branch. Ifosfamide
(IFOS) is known as an anticancer and cytotoxic drug especially on the liver. This study aimed …
(IFOS) is known as an anticancer and cytotoxic drug especially on the liver. This study aimed …
Ehretia laevis mitigates paracetamol-induced hepatotoxicity by attenuating oxidative stress and inflammation in rats
Hepatotoxicity is caused due to intake of drug or any chemical above the therapeutic range
or as overdose. Current therapies for the management of hepatotoxicity are associated with …
or as overdose. Current therapies for the management of hepatotoxicity are associated with …
Mancozeb-induced hepatotoxicity: protective role of curcumin in rat animal model
JS Aprioku, AM Amamina… - Toxicology Research, 2023 - academic.oup.com
Background Mancozeb—a widely used fungicide in the agricultural sector—is believed to
cause toxicity by increasing oxidative stress. This work investigated the efficacy of curcumin …
cause toxicity by increasing oxidative stress. This work investigated the efficacy of curcumin …