Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …

Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …

Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …

Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy
(HCM), a disorder of heart muscle thickening associated with sudden cardiac death and …

Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited
cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins …

With stress echo (SE) 2020 study, a new standard of practice in stress imaging was
developed and disseminated: the ABCDE protocol for functional testing within and beyond …

Aims: Ventricular arrhythmia triggers sudden cardiac death (SCD) in hypertrophic
cardiomyopathy (HCM), yet electrophysiological biomarkers are not used for risk …

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease with
heterogeneous clinical presentations, governed by multiple molecular mechanisms …

Heritable cardiomyopathies are a class of heart diseases caused by variations in a number
of genetic loci. Genetic variants on one allele lead to either a degraded protein, which …