Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Regulatory T (Treg) cells constitute a dynamic population that is essential for controlling
immune responses in health and disease. Defects in Treg cell function and decreases in …

The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We
previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios …

The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their
intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

In the last two years, clinical trials with blocking antibodies to the negative checkpoint
regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple …

Purpose: T-cell immunoglobulin and ITIM domain (TIGIT), a member of the immune
checkpoint family, is important in normal T-cell biology. However, the phenotypical profile …

Regulatory T cells (Tregs) play a central role in counteracting inflammation and
autoimmunity. A more complete understanding of cellular heterogeneity and the potential for …