The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …

Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes
containing a zinc ion in the active site. They are secreted from cells or bound to the plasma …

Carbonic anhydrase IX (CAIX) is a hypoxia inducible factor 1-induced, cell surface pH
regulating enzyme with an established role in tumor progression and clinical outcome …

In rheumatoid arthritis, the coordinated expansion of the synoviocyte mass is coupled with a
pathologic angiogenic response that leads to the destructive remodeling of articular as well …

For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been
recognized as a key component in cancer progression. Initially, the primary roles assigned …

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I
transmembrane metalloproteinase involved in pericellular proteolysis, migration and …

The discoidin domain receptors (DDRs) are receptor tyrosine kinases that upon binding to
collagens undergo receptor phosphorylation, which in turn activates signal transduction …

Eph receptor tyrosine kinases are considered candidate therapeutic targets in cancer, but
they can exert opposing effects on cell growth. In the presence of its ligands, Eph receptor …

Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases
(MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly …

Pericellular proteolysis by membrane-type 1 matrix metalloproteinase (MT1-MMP) plays a
pivotal role in tumor cell invasion. Localization of MT1-MMP at the invasion front of cells, eg …