Need of orthogonal approaches in neurological disease modeling in mouse

L Bossini, A Sessa - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
Over the years, advancements in modeling neurological diseases have revealed innovative
strategies aimed at gaining deeper insights and developing more effective treatments for …

New insights into suicidal behavior from large multi-ancestry genetic meta-analysis

EB Binder - American journal of psychiatry, 2023 - Am Psychiatric Assoc
Suicide is the second leading cause of death among 15-to 29-year-olds (1), and a history of
psychiatric disorders is one of the main risk factors. Hence, understanding the causes of and …

Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior

D Spengler, T Rein - Signal transduction and targeted therapy, 2024 - nature.com
In a study recently published in Nature, Cathomas et al. 1 report that social stress in mice
increases the levels of matrix metalloprotease (MMP) 8 in circulating immune cells, thereby …