With the development of modern chemistry and biology, non-proteinogenic amino acids
(NPAAs) have become a powerful tool for developing peptide-based drug candidates. Drug …

Peptide/protein therapeutics have been significantly applied in the clinical treatment of
various diseases such as cancer, diabetes, etc. owing to their high biocompatibility …

Abstract Glucagon-like peptide-1 (GLP-1), secreted by L cells in the small intestine, assumes
a central role in managing type 2 diabetes mellitus (T2DM) and obesity. Its influence on …

Oxyntomodulin (OXM) is an intestinal peptide hormone that activates both glucagon-like
peptide-1 (GLP-1) and glucagon (GCG) receptors. The natural peptide reduces body weight …

Bariatric surgery results in increased intestinal secretion of hormones GLP-1 and
anorexigenic PYY, which is believed to contribute to the clinical efficacy associated with the …

Peptide drugs have the advantages of target specificity and good drugability and have
become one of the most increasingly important hotspots in new drug research in biomedical …

A stapled α-helix peptide library was designed and constructed using a chemically modified
phage display system for screening stapled-peptide ligands against target proteins. The α …

Venom peptides have been evolving complex therapeutic interventions that potently and
selectively modulate a range of targets such as ion channels, receptors, and signaling …

Anorexigenic peptides offer promise as potential therapies targeting the escalating global
obesity epidemic. Prolactin-releasing peptide (PrRP), a novel member of the RFamide family …

Peptides are considered as potent therapeutic drugs primarily due to the exquisite potency
and selectivity to targets. However, the development and clinical application of peptide …