Helminth immunomodulation in autoimmune disease

TB Smallwood, PR Giacomin, A Loukas… - Frontiers in …, 2017 - frontiersin.org
Helminths have evolved to become experts at subverting immune surveillance. Through
potent and persistent immune tempering, helminths can remain undetected in human …

Immunology of alveolar and cystic echinococcosis (AE and CE)

B Gottstein, P Soboslay, E Ortona, J Wang… - Advances in …, 2017 - Elsevier
Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the
cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus …

Fasciola hepatica-Derived Molecules as Regulators of the Host Immune Response

S Ryan, J Shiels, CC Taggart, JP Dalton… - Frontiers in …, 2020 - frontiersin.org
Helminths (worms) are one of the most successful organisms in nature given their ability to
infect millions of humans and animals worldwide. Their success can be attributed to their …

How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

I Camaya, B O'Brien, S Donnelly - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a
faster rate than heart disease and cancer. While the disease presents clinically as chronic …

Helminth-derived biomacromolecules as therapeutic agents for treating inflammatory and infectious diseases: What lessons do we get from recent findings?

P Chakraborty, V Aravindhan, S Mukherjee - International Journal of …, 2023 - Elsevier
Despite the tremendous progress in healthcare sectors, a number of life-threatening
infectious, inflammatory, and autoimmune diseases are continuously challenging mankind …

Parasite-derived proteins for the treatment of allergies and autoimmune diseases

Z Wu, L Wang, Y Tang, X Sun - Frontiers in microbiology, 2017 - frontiersin.org
The morbidity associated with atopic diseases and immune dysregulation disorders such as
asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and …

The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal …

R Alvarado, J To, ME Lund, A Pinar… - The FASEB …, 2017 - Wiley Online Library
The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL‐
1β, a cytokine that influences the development of both innate and adaptive immune …

[HTML][HTML] The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

LC Laan, AR Williams, K Stavenhagen, M Giera… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Clinical trials have shown that administration of the nematode Trichuris suis can be
beneficial in treating various immune disorders. To provide insight into the mechanisms by …

[HTML][HTML] Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

M Maatouk, D Elgueder, N Mustapha… - Cell Stress and …, 2016 - Elsevier
Naringenin is one of the most popular flavonoids derived from citrus. It has been reported to
be an effective anti-inflammatory compound. Citrus fruit may be used raw, cooked, stewed …

Manipulating autophagic processes in autoimmune diseases: a special focus on modulating chaperone-mediated autophagy, an emerging therapeutic target

F Wang, S Muller - Frontiers in immunology, 2015 - frontiersin.org
Autophagy, a constitutive intracellular degradation pathway, displays essential role in the
homeostasis of immune cells, antigen processing and presentation, and many other immune …