Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Simple Summary Bone metastases represent a serious and common challenge in advanced
cancer patients, making early detection crucial. The growing implementation of artificial …

Bone is one of the most common sites of metastasis from advanced solid tumors. Bone
metastasis is a leading cause of pain and increases the risk of skeletal-related events …

Background Bones are one of the most common metastatic sites for solid malignancies.
Bone metastases can significantly increase mortality and decrease the quality of life of …

Osteoimmunology was coined about twenty years ago to identify a strict cross talk between
bone niche and immune system both in physiological and pathological activities, including …

Background: Bone is the most common metastatic site associated with breast cancer. Using
a database of women with breast cancer treated at Guy's Hospital, London 1976–2006 and …

Purpose To evaluate the incidence, clinicopathological characteristics, treatment outcomes,
prognostic factors, and survival of gastric cancer patients with bone metastases. Materials …

There are currently no targeted delivery systems to satisfactorily treat bone-related
disorders. Many clinical drugs consisting of small organic molecules have a short circulation …

Background Bone metastasis is relatively uncommon in gastric cancer patients, but its
incidence has been rising. Early detection of bone metastasis is important in preventing …

Skeletal metastases of unknown primary (SMUP) represent a clinical challenge in dealing
with patients diagnosed with bone metastases. Management of these patients has improved …