Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

The introduction of noncanonical amino acids into proteins and peptides has been of great
interest for many years and has facilitated the detailed study of peptide/protein structure and …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Synthetic biology holds promise to revolutionize the life sciences and biomedicine via
expansion of macromolecular diversity outside the natural chemical space. Use of non …

Reversible phosphorylation is a fundamental mechanism for controlling protein function.
Despite the critical roles phosphorylated proteins play in physiology and disease, our ability …

The ribosome produces all of the proteins and many of the peptides present in cells. As a
macromolecular complex composed of both RNAs and proteins, it employs a constituent …

Phosphotyrosine-containing compounds attract significant attention due to their potential to
modulate signalling pathways by binding to phospho-writers, erasers and readers such as …

Protein phosphorylation is a reversible, residue-specific posttranslational modification that
plays a pivotal role in cell signaling, and the phosphorylation state of proteins is tightly …

Protein tyrosine phosphorylation plays a critical role in signal transduction. We report the
genetic incorporation of a phosphotyrosine (pTyr) analog, p-carboxymethyl-L-phenylalanine …