Acyclic twisted amides

G Meng, J Zhang, M Szostak - Chemical reviews, 2021 - ACS Publications
In this contribution, we provide a comprehensive overview of acyclic twisted amides,
covering the literature since 1993 (the year of the first recognized report on acyclic twisted …

Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

[HTML][HTML] Macrocyclization reactions: the importance of conformational, configurational, and template-induced preorganization

V Marti-Centelles, MD Pandey, MI Burguete… - Chemical …, 2015 - ACS Publications
Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Where biology and traditional polymers meet: The potential of associating sequence-defined polymers for materials science

AJ DeStefano, RA Segalman, EC Davidson - Jacs Au, 2021 - ACS Publications
Polymers with precisely defined monomeric sequences present an exquisite tool for
controlling material properties by harnessing both the robustness of synthetic polymers and …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Strategies for fine-tuning the conformations of cyclic peptides

R Jwad, D Weissberger, L Hunter - Chemical Reviews, 2020 - ACS Publications
Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Applications of discrete synthetic macromolecules in life and materials science: recent and future trends

R Aksakal, C Mertens, M Soete, N Badi… - Advanced …, 2021 - Wiley Online Library
In the last decade, the field of sequence‐defined polymers and related ultraprecise,
monodisperse synthetic macromolecules has grown exponentially. In the early stage, mainly …

Peptides and peptidomimetics for antimicrobial drug design

B Mojsoska, H Jenssen - Pharmaceuticals, 2015 - mdpi.com
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …

Chemistry of bridged lactams and related heterocycles

M Szostak, J Aube - Chemical reviews, 2013 - ACS Publications
The amide bond is one of the most important functional groups in chemistry and biology. 1
Due to the strong resonance interaction between nN and π* C O orbitals (Figure 1), 2 the …