Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Covalent adaptable networks (CANs), unlike typical thermosets or other covalently
crosslinked networks, possess a unique, often dormant ability to activate one or more forms …

Over the last decades, the fabrication of 3D tissues has become commonplace in tissue
engineering and regenerative medicine. However, conventional 3D biofabrication …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Humans and animals lose tissues and organs due to congenital defects, trauma, and
diseases. The human body has a low regenerative potential as opposed to the urodele …

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization …

Hydrogels comprised of alginate and gelatin have demonstrated potential as biomaterials in
three dimensional (3D) bioprinting applications. However, as with all hydrogel-based …

The extracellular matrix (ECM) is a complex and dynamic meshwork of cross-linked proteins
that supports cell polarization and functions and tissue organization and homeostasis. Over …

Regenerative strategies such as stem cell-based therapies and tissue engineering
applications are being developed with the aim to replace, remodel, regenerate or support …