Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and
septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To …

Most bacteria pathogenic for humans have closely related nonpathogenic counterparts that
live as saprophytes, commensals or even symbionts (mutualists) in similar or different …

The aerotolerant anaerobe Streptococcus pneumoniae is part of the normal nasopharyngeal
microbiota of humans and one of the most important invasive pathogens. A genomic survey …

High levels of copper are toxic and therefore bacteria must limit free intracellular levels to
prevent cellular damage. In this study, we show that a number of pneumococcal genes are …

In Gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite
control mechanisms. In the human pathogen Streptococcus pneumoniae, links between …

The human pathogen Streptococcus pneumoniae is a strictly fermentative organism that
relies on glycolytic metabolism to obtain energy. In the human nasopharynx S. pneumoniae …

Background Host signals are being shown to have a major impact on the bacterial
phenotype. One of them is the endogenously produced catecholamine stress hormones …

Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus
aureus is a leading cause of biofilm infections on medical devices, including prosthetic …

Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in
humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the …

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Mtb is
persistently exposed to numerous oxidoreductive stresses during its pathogenic cycle of …