Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

M Friedel, IAP Thompson, G Kasting, R Polsky… - Nature Biomedical …, 2023 - nature.com
The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet,
collecting diagnostically useful ISF is more challenging than collecting blood because the …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

Microneedle-based biosensing

LK Vora, AH Sabri, PE McKenna, A Himawan… - Nature Reviews …, 2024 - nature.com
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally
invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the …

Poloxamer hydrogels for biomedical applications

E Russo, C Villa - Pharmaceutics, 2019 - mdpi.com
This review article focuses on thermoresponsive hydrogels consisting of poloxamers which
are of high interest for biomedical application especially in drug delivery for ophthalmic …

Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

BHJ Gowda, MG Ahmed, U Hani, P Kesharwani… - International Journal of …, 2023 - Elsevier
Psoriasis is a chronic, autoimmune, and non-communicable skin disease with a worldwide
prevalence rate of 2–3%, creating an economic burden on global health. Some significant …

A review on solid microneedles for biomedical applications

N Tariq, MW Ashraf, S Tayyaba - Journal of Pharmaceutical Innovation, 2022 - Springer
Microelectromechanical system (MEMS)-based microneedles are an innovative way of drug
delivery that increases the permeability of the skin. It generates microscopic pores inside the …

Microneedle patch designs to increase dose administered to human subjects

W Li, S Li, X Fan, MR Prausnitz - Journal of Controlled Release, 2021 - Elsevier
Microneedle (MN) patches are being developed for many different kinds of drugs, but are
often limited to delivering sub-milligram doses. This is because larger patches can be more …

Microneedle arrays for drug delivery and diagnostics: toward an optimized design, reliable insertion, and penetration

V Ebrahiminejad, PD Prewett… - Advanced Materials …, 2022 - Wiley Online Library
In the past two decades, microneedles have been extensively studied for transdermal
delivery of drug or vaccines and for bio‐fluid extraction. Microneedle‐based devices consist …

Ocular delivery of predatory bacteria with cryomicroneedles against eye infection

M Cui, M Zheng, C Wiraja, SWT Chew… - Advanced …, 2021 - Wiley Online Library
The development of potent antibiotic alternatives with rapid bactericidal properties is of great
importance in addressing the current antibiotic crisis. One representative example is the …

Minimally invasive capillary blood sampling methods

MSF Hoffman, JW McKeage, J Xu… - Expert review of …, 2023 - Taylor & Francis
Introduction Whole blood samples, including arterial, venous, and capillary blood, are
regularly used for disease diagnosis and monitoring. The global Covid-19 pandemic has …