Evaluation and management of esophageal and gastric varices in patients with cirrhosis

SS Jakab, G Garcia-Tsao - Clinics in liver disease, 2020 - liver.theclinics.com
Esophageal varices are the most common type of gastroesophageal varices, with a
prevalence of 50% to 60% among patients with cirrhosis, and up to 85% in patients with …

The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines

GM Hirschfield, JK Dyson, GJM Alexander… - Gut, 2018 - gut.bmj.com
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …

Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receiving ursodeoxycholic acid therapy

WJ Lammers, GM Hirschfield, C Corpechot, F Nevens… - Gastroenterology, 2015 - Elsevier
Background & Aims Approaches to risk stratification for patients with primary biliary cirrhosis
(PBC) are limited, single-center based, and often dichotomous. We aimed to develop and …

[PDF][PDF] Risk stratification in autoimmune cholestatic liver diseases: opportunities for clinicians and trialists

PJ Trivedi, C Corpechot, A Pares, GM Hirschfield - Hepatology, 2016 - Wiley Online Library
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent
autoimmune cholestatic liver diseases, that disproportionate to their incidence and …

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

PJ Trivedi, WJ Lammers, HR Van Buuren, A Parés… - Gut, 2016 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary
biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to …

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response

PJ Trivedi, T Bruns, A Cheung, KK Li, C Kittler… - Journal of …, 2014 - Elsevier
Background & Aims Outcomes in primary biliary cirrhosis (PBC) can be predicted by
biochemical response to ursodeoxycholic acid (UDCA). Such stratification inadequately …

Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: risk factors and time trends in incidence and outcome

MH Harms, WJ Lammers, D Thorburn… - Official journal of the …, 2018 - journals.lww.com
OBJECTIVES: In this era of near universal ursodeoxycholic acid (UDCA) treatment for
primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important …

Non-invasive prediction of high-risk varices in patients with primary biliary cholangitis and primary sclerosing cholangitis

C Moctezuma-Velazquez, F Saffioti… - Official journal of the …, 2019 - journals.lww.com
BACKGROUND: Baveno-VI guidelines recommend that patients with compensated cirrhosis
with liver stiffness by transient elastography (LSM-TE)< 20 kPa and platelets> 150,000/mm 3 …

Effects of age and sex of response to ursodeoxycholic acid and transplant-free survival in patients with primary biliary cholangitis

AC Cheung, WJ Lammers, CFM Perez… - Clinical …, 2019 - Elsevier
Background & Aims Primary biliary cholangitis (PBC) predominantly affects middle-aged
women; there are few data on disease phenotypes and outcomes of PBC in men and …

Validation of risk scoring systems in ursodeoxycholic acid–treated patients with primary biliary cholangitis

C Efe, K Taşçilar, I Henriksson, E Lytvyak… - Official journal of the …, 2019 - journals.lww.com
METHODS: We performed a study on data of 1746 UDCA-treated patients with PBC from 25
centers in Europe, United States, and Canada. The prognostic performance of the risk …