Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell
carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

The devastating link between tobacco products and human cancers results from a powerful
alliance of two factors—nicotine and carcinogens. Without either one of these, tobacco …

The purpose of this paper is to review the epidemiologic evidence for the effects of tobacco
use and tobacco use cessation on a variety of oral diseases and conditions. Exposures …

Abstract Using the International Project on Genetic Susceptibility to Environmental
Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

Breast cancer is the most frequent cancer in women and represents the second leading
cause of cancer death among women (after lung cancer). The etiology of breast cancer is …

Much is now known about the carcinogens in cigarette smoke, their conversion to forms that
react with DNA, and the miscoding properties of the resulting DNA adducts that cause the …

ContextLittle is known about genetic susceptibility to cigarette smoke in relation to adverse
pregnancy outcomes. ObjectiveTo investigate whether the association between maternal …