Recent development in indole derivatives as anticancer agent: A mechanistic approach

N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Y Zhang, C Hu - Archiv der Pharmazie, 2020 - Wiley Online Library
The bisindole moiety, as a versatile pharmacophore, is one of the widespread heterocycles
in naturally occurring and synthetic bioactive compounds. The bisindole alkaloids derived …

Design, synthesis ADMET and molecular docking of new imidazo [4, 5-b] pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors

IMM Othman, MAM Gad-Elkareem, K Aouadi… - Bioorganic …, 2020 - Elsevier
In our effort of discovering new antimicrobial agents, a novel series of imidazo [4, 5-b]
pyridine-5-thione scaffolds were designed and synthesized and their chemical structures …

Construction of Imidazole-Fused-Ring Systems by Iron-Catalyzed C(sp3)-H Amination–Cyclization under Aerobic Conditions

J Peng, S Li, J Huang, Q Meng, L Wang… - The Journal of …, 2023 - ACS Publications
An iron-catalyzed efficient C–H amination for the construction of imidazole-fused-ring
systems was developed under aerobic conditions. Compared to previous studies, this work …

New imidazo [2, 1-b] thiazole-based aryl hydrazones: unravelling their synthesis and antiproliferative and apoptosis-inducing potential

MA Shareef, GP Devi, SR Routhu, CG Kumar… - RSC Medicinal …, 2020 - pubs.rsc.org
Herein, we have designed and synthesized new imidazo [2, 1-b] thiazole-based aryl
hydrazones (9a–w) and evaluated their anti-proliferative potential against a panel of human …

[HTML][HTML] Design, synthesis and anticancer activity of new polycyclic: Imidazole, thiazine, oxathiine, pyrrolo-quinoxaline and thienotriazolopyrimidine derivatives

AA Abu-Hashem, SA Al-Hussain, MEA Zaki - Molecules, 2021 - mdpi.com
In this article, we showed the synthesis of new polycyclic aromatic compounds, such as
thienotriazolopyrimidinones, N-(thienotriazolopyrimidine) acetamide, 2-mercapto …

A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway‐Mediated Apoptosis

J Wang, H Wu, G Song, D Yang… - BioMed Research …, 2020 - Wiley Online Library
Background. Cancer remains a major clinical challenge because of the lack of effective drug
for its treatment. To find out novel cancer chemotherapeutic molecules, we explored the …

Synthesis, characterization, DFT, ADMET, MD analysis and molecular docking of C-3 functionalized imidazo [1, 2-a] pyridine motifs

W Daoudi, M Azzouzi, M Aaddouz… - Journal of Molecular …, 2024 - Elsevier
Abstract Imidazo [1, 2-a] pyridine is a motif of crucial importance in organic chemistry, widely
explored for its diverse applications in the synthesis of biologically active compounds …

An autophagy-related long non-coding RNA signature for breast cancer

F Jiang, C Wu, M Wang, K Wei… - … Chemistry & High …, 2022 - ingentaconnect.com
Background: The most prevalent malignant tumor in women is breast cancer (BC). As
autophagic therapies have been identified to contribute to BC cell death, the potential …

Enzymatic Synthesis of Indole‐Based Imidazopyridine using α‐Amylase

P Kamboj, V Tyagi - ChemBioChem, 2024 - Wiley Online Library
Abstract The imidazo [1, 2‐a] pyridine scaffold has gained significant attention due to its
presence as a lead structure in several commercially available pharmaceuticals like …