A viral biomolecular condensate coordinates assembly of progeny particles

M Charman, N Grams, N Kumar, E Halko, JM Dybas… - Nature, 2023 - nature.com
Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes,. Emerging evidence has suggested that membraneless subcellular …

[HTML][HTML] E4orf1: The triple agent of adenovirus–Unraveling its roles in oncogenesis, infectious obesity and immune responses in virus replication and vector therapy

L Göttig, S Schreiner - Tumour Virus Research, 2024 - Elsevier
Abstract Human Adenoviruses (HAdV) are nearly ubiquitous pathogens comprising
numerous sub-types that infect various tissues and organs. Among many encoded proteins …

The adenovirus DNA-binding protein DBP

LD Bertzbach, L Seddar, K von Stromberg… - Journal of …, 2024 - Am Soc Microbiol
Adenoviruses are a group of double-stranded DNA viruses that can mainly cause
respiratory, gastrointestinal, and eye infections in humans. In addition, adenoviruses are …

Global transcriptome analyses of cellular and viral mRNAs during HAdV-C5 infection highlight new aspects of viral mRNA biogenesis and cytoplasmic viral mRNA …

MV Alemán, LD Bertzbach, T Speiseder, WH Ip… - Viruses, 2022 - mdpi.com
It is well established that human adenoviruses such as species C, types 2 and 5 (HAdV-C2
and HAdV-C5), induce a nearly complete shutoff of host-cell protein synthesis in the infected …

Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis

DF Edwards, III, EA Pereira, LA Castro-Jorge… - Journal of …, 2024 - journals.asm.org
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by
autophosphorylation in response to double strand DNA (dsRNA) and other stimuli. Activated …

[HTML][HTML] The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro

WH Ip, LD Bertzbach, T Speiseder, T Dobner - Tumour Virus Research, 2023 - Elsevier
The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several
distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement …

The Applications of Nanopore Sequencing Technology in Animal and Human Virus Research

CM Ji, XY Feng, YW Huang, RA Chen - Viruses, 2024 - mdpi.com
In recent years, an increasing number of viruses have triggered outbreaks that pose a
severe threat to both human and animal life, as well as caused substantial economic losses …

Adenovirus Transcriptome in Human Cells Infected with ChAdOx1-Vectored Candidate HIV-1 Vaccine Is Dominated by High Levels of Correctly Spliced …

DA Matthews, R Milligan, EG Wee, T Hanke - Vaccines, 2023 - mdpi.com
We develop candidate HIV-1 vaccines, of which two components, ChAdOx1. tHIVconsv1
(C1) and ChAdOx1. HIVconsv62 (C62), are delivered by the simian adenovirus-derived …

Analysis of Fowl Adenovirus 4 Transcriptome by De Novo ORF Prediction Based on Corrected Nanopore Full-Length cDNA Sequencing Data

Z Lu, Y Wang, X Zou, T Hung - Viruses, 2023 - mdpi.com
The transcriptome of fowl adenovirus has not been comprehensively revealed. Here, we
attempted to analyze the fowl adenovirus 4 (FAdV-4) transcriptome by deep sequencing …

[HTML][HTML] Nanopore Guided Annotation of Transcriptome Architectures

JS Abebe, Y Alwie, E Fuhrmann, J Leins, J Mai… - bioRxiv, 2024 - ncbi.nlm.nih.gov
High-resolution annotations of transcriptomes from all domains of life are essential for many
sequencing-based RNA analyses, including Nanopore direct RNA sequencing (DRS) …