Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone
remarkable changes during the past decade. This review addresses the latest ideas …

B cell chronic lymphocytic leukemia (B-CLL) is an accumulative disease of slowly
proliferating CD5+ B lymphocytes that develops in the aging population. Whereas some …

Previous studies suggest that the diversity of the expressed variable (V) region repertoire of
the immunoglobulin (Ig) H chain of B-CLL cells is restricted. Although limited examples of …

Studies of B cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients
with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some …

Several studies suggest that immune‐mediated pathways are important in the pathogenesis
of chronic lymphocytic leukaemia (CLL). The in vivo accumulation of leukaemic lymphocytes …

During fetal development, murine and human B-lineage cells rearrange and express a
highly restricted set of immunoglobulin heavy chain variable region genes (VH genes). We …

Publisher Summary The international nomenclature established for cell differentiation
antigens will be used. Historically, the CD5 B cell in mice or humans has been referred to as …

To investigate the molecular basis of the autoimmune response to the related i and I
carbohydrate antigens, we studied cold agglutinins (CA) from B-cell clones and from the …

Major advances have occurred in our understanding of the biology, immunology, and
opportunities for treatment of chronic lymphocytic leukemia (CLL) in recent times. Surface …

The clinical efficacy of B cell targeting therapies highlights the pathogenic potential of B cells
in inflammatory diseases. Expression of Fc Receptor like 4 (FcRL4) identifies a memory B …