Cellular trafficking is essential to maintain critical biological functions. Mutations in 346
genes, most of them described in the last 5 years, are associated with disorders of cellular …

The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption,
digestion, secretion, and elimination of waste products that also hosts immune surveillance …

Objective To assess the benefit of the recombinant human interleukin‐1 receptor antagonist
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …

Organoid technology allows the expansion of primary epithelial cells from normal and
diseased tissues, providing a unique model for human (patho) biology. In a three …

Intestinal epithelial cells absorb nutrients through the brush border, composed of dense
arrays of highly ordered microvilli at their apical membranes. A protocadherin-based …

Members of the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor
(SNARE) family mediate membrane fusion processes associated with vesicular trafficking …

STXBP2, encoding syntaxin-binding protein 2, is involved in intracellular organelle
trafficking and is associated with familial hemophagocytic lymphohistiocytosis type 5 …

Microvillus inclusion disease (MVID) is a rare congenital severe malabsorptive and
secretory diarrheal disease characterized by blunted or absent microvilli with accumulation …

Haematopoietic stem cell transplantation currently remains the only curative treatment of
primary forms of haemophagocytic lymphohistiocytosis (HLH). Rapid diagnosis, efficient …

Engineered nanomaterials (ENMs) have become common in the food industry, which
motivates the need to evaluate ENM effects on human health. Gastrointestinal (GI) in vitro …