Despite recent advances in our understanding of the biological basis of prostate cancer, the
management of the disease, especially in the castration-resistant phase, remains a …

Neutrophil serine proteases are granule-associated enzymes known mainly for their function
in the intracellular killing of pathogens. Their extracellular release upon neutrophil activation …

Polymorphonuclear granulocytes (PMNs; neutrophils) serve as key effector cells in the
innate immune system and provide the first line of defense against invading …

Resistance to cell death is a hallmark of cancer. Autophagy is a survival mechanism
activated in response to nutrient deprivation; however, excessive autophagy will ultimately …

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in
killing pathogens. Studies over the past several years indicate that cathepsin G has …

The host response to tissue injury and/or infection is dependent on the action of numerous
extracellular proteases. Proteolytic cascades trigger blood clotting, fibrinolysis, and …

Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to
danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long …

Contributions from multiple cathepsins within endosomal antigen processing compartments
are necessary to process antigenic proteins into antigenic peptides. Cysteine and aspartyl …

Neutrophils are the most abundant immune cell in the circulation of human and act as
gatekeepers to discard foreign elements that have entered the body. They are essential in …

Dysregulated protease activity has long been implicated in the pathogenesis of chronic lung
diseases and especially in conditions that display mucus obstruction, such as chronic …