RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Genome instability is a feature of cancer cells, transcription being an important source of
DNA damage. This is in large part associated with R-loops, which hamper replication …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA,
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …

Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …

DEAD-box RNA helicases are important regulators of RNA metabolism and have been
implicated in the development of cancer. Interestingly, these helicases constitute a major …

Prolonged pausing of the transcription machinery may lead to the formation of three-
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …