Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Abstract Treatment of sepsis remains a significant challenge with persisting high mortality
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

Objectives: To outline the concepts involved in optimizing antibacterial dosing in critically ill
patients with acute renal failure undergoing continuous renal replacement therapy (CRRT) …

The purpose of this randomized, multicenter, open-label study was to compare the
continuous infusion of piperacillin-tazobactam with the standard intermittent infusion in 262 …

Steady-state plasma and intrapulmonary concentrations of cef... : Critical Care Medicine
Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous …

Infections and related sepsis are two of the most prevalent issues in the care of critically ill
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …

Antibiotic pharmacodynamics is an evolving science that focuses on the relationship
between drug concentration and pharmacologic effect, which is an antibiotic‐induced …

The aim of this study was to compare the pharmacokinetic and pharmacodynamic
parameters of a continuous in-fusion of cefepime vs. an intermittent regimen in critically ill …