High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2
deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other …

WEE1 is a checkpoint kinase critical for mitotic events, especially in cell maturation and DNA
repair. Most cancer cells' progression and survival are linked with elevated levels of WEE1 …

Cancer homeostasis depends on a balance between activated oncogenic pathways driving
tumorigenesis and engagement of stress response programs that counteract the inherent …

For one-third of patients with pediatric cancer enrolled in precision medicine programs,
molecular profiling does not result in a therapeutic recommendation. To identify potential …

Hyperactive FMS-like receptor tyrosine kinase-3 mutants with internal tandem duplications
(FLT3-ITD) are frequent driver mutations of aggressive acute myeloid leukemia (AML) …

Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …

Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

Summary BCR:: ABL1-independent pathways contribute to primary resistance to tyrosine
kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) and play a role in …

Hyperthermic intraperitoneal chemotherapy's role in ovarian cancer remains controversial,
hindered by limited understanding of hyperthermia-induced tumor cellular changes. This …