Mechanisms of oxidized LDL-mediated endothelial dysfunction and its consequences for the development of atherosclerosis

H Jiang, Y Zhou, SM Nabavi, A Sahebkar… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative
stress, epigenetics, and metabolic dysfunction. There is compelling evidence suggesting …

Role of myeloperoxidase in inflammation and atherosclerosis

C Frangie, J Daher - Biomedical reports, 2022 - spandidos-publications.com
Myeloperoxidase (MPO) belongs to the heme peroxidase family, which includes a set of
enzymes with potent oxidoreductase activity. MPO is considered an important part of the …

[HTML][HTML] Novel insight on the role of Macrophages in atherosclerosis: Focus on polarization, apoptosis and efferocytosis

Y Xie, H Chen, P Qu, X Qiao, L Guo, L Liu - International …, 2022 - Elsevier
Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases, which is
mainly characterized by lipid deposition and inflammatory response. Macrophages (MΦ), as …

Identification of crosstalk genes and immune characteristics between Alzheimer's disease and atherosclerosis

W An, J Zhou, Z Qiu, P Wang, X Han, Y Cheng… - Frontiers in …, 2024 - frontiersin.org
Background Advancements in modern medicine have extended human lifespan, but they
have also led to an increase in age-related diseases such as Alzheimer's disease (AD) and …

[HTML][HTML] A Potential Link between Myeloperoxidase Modified LDL, Atherosclerosis and Depression

J Daher - International Journal of Molecular Sciences, 2024 - mdpi.com
Atherosclerosis is a chronic inflammatory disease that involves modified low-density
lipoproteins (LDL) which play a pivotal role in the initiation and progression of the disease …

Pharmacological therapy targeting the immune response in atherosclerosis

Y Wu, Y Xu, L Xu - International Immunopharmacology, 2024 - Elsevier
Atherosclerosis (AS) is a chronic inflammatory disease characterized by the formation of
atherosclerotic plaques that consist of numerous cells including smooth muscle cells …

Exploring the role of myeloperoxidase in the atherosclerotic process in hypoxic mice based on the MAPK signaling pathway

J Zhang, Y Han, R Jia, Q Zhu, X Wang, M Liu… - Biochemical …, 2024 - Elsevier
Atherosclerosis (AS) is the common pathophysiological basis of various cardiovascular
diseases and the leading cause of death from cardiovascular disease worldwide. When the …

The in vitro effect of myeloperoxidase oxidized LDL on THP-1 derived macrophages

E Jeradeh, C Frangie, S Bazzi, J Daher - Innate Immunity, 2024 - journals.sagepub.com
Cardiovascular diseases (CVDs) linked to atherosclerosis remains the leading cause of
death worldwide. Atherosclerosis is primarily caused by the accumulation of oxidized forms …

Novel Insights into the Link Between Myeloperoxidase Modified LDL, LOX-1, and Neuroserpin in Stroke

L El-Hajjar, E Miranda, M El-Sabban… - Reviews in …, 2023 - iris.uniroma1.it
Background: Cardiovascular disease that is caused by atherosclerosis is the leading cause
of death worldwide. Atherosclerosis is primarily triggered by endothelial dysfunction and the …

Identification of immuno-inflammation-related biomarkers for acute myocardial infarction based on bioinformatics

H You, M Dong - Journal of Inflammation Research, 2023 - Taylor & Francis
Purpose Previous studies have confirmed that inflammation and immunity are involved in
the pathogenesis of acute myocardial infarction (AMI). However, only few related genes are …