The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair.
A key part of the regenerative response is the transient reprogramming of epithelial cells into …

The formation of multiple cysts in the liver occurs in a number of isolated monogenic
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …

Wnt and Rspondin (RSPO) signaling drives proliferation, and bone morphogenetic protein
inhibitors (BMPi) impede differentiation, of intestinal stem cells (ISCs). Here, we identify the …

How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal
organoids offer a model of self-organization as they generate stem cell zones (SCZs) of …

Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental
understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal …

Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …

Paneth cells are professional secretory cells that, classically, play a role in the innate
immune system by secreting antimicrobial factors into the lumen to control enteric bacteria …