Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …

Objectives Prior studies noted that chondrocyte SIRT6 activity is repressed in older
chondrocytes rendering cells susceptible to catabolic signalling events implicated in …

Objective Osteoarthritis (OA) is a leading cause of chronic pain, yet OA pain management
remains poor. Age is the strongest predictor of OA development, and mechanisms driving …

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …

Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no
effective treatments are currently available. Arterial hypertension is a common comorbidity in …

Objectives Histological scoring remains the gold-standard for quantifying post-traumatic
osteoarthritis (ptOA) in animal models, allowing concurrent evaluation of numerous joint …

This study aims to develop a comprehensive and easily executable histopathologic grading
scheme for murine knee osteoarthritis (OA) using specific scoring criteria for both cartilage …

Objective The study objective was to determine whether overexpression of the mitochondrial
antioxidant peroxidase, peroxiredoxin 3 (Prx3), reduces the severity of osteoarthritis (OA) in …

Post-menopausal women present with the highest incidence and morbidity of knee
osteoarthritis (KOA), but no disease-modifying therapies are available. This treatment gap …