Spare and repair the gut microbiota from antibiotic-induced dysbiosis: state-of-the-art

A Andremont, J Cervesi, PA Bandinelli, F Vitry… - Drug Discovery …, 2021 - Elsevier
Highlights•The gut microbiota is regarded nowadays as a key component for human
health.•Dysbiosis is an unrecognized disease whose consequences just begin to be …

Microbiota restoration for recurrent Clostridioides difficile: Getting one step closer every day!

S Khanna - Journal of Internal Medicine, 2021 - Wiley Online Library
Clostridioides difficile infection (CDI) is an urgent health threat being the most common
healthcare‐associated infection, and its management is a clinical conundrum. Over 450 000 …

The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial …

M Messaoudene, S Ferreira, N Saint-Lu… - Nature …, 2024 - nature.com
The deleterious impact of antibiotics (ATB) on the microbiome negatively influences immune
checkpoint inhibitors (ICI) response in patients with cancer. We conducted a randomized …

An open randomized multicentre Phase 2 trial to assess the safety of DAV132 and its efficacy to protect gut microbiota diversity in hospitalized patients treated with …

MJGT Vehreschild, A Ducher, T Louie… - Journal of …, 2022 - academic.oup.com
Background DAV132 (colon-targeted adsorbent) has prevented antibiotic-induced effects on
microbiota in healthy volunteers. Objectives To assess DAV132 safety and biological …

Non-antibiotic drugs break colonization resistance against pathogenic Gammaproteobacteria

A Grießhammer, J de la Cuesta-Zuluaga, T Zahir… - bioRxiv, 2023 - biorxiv.org
Non-antibiotic drugs can alter the composition of the gut microbiome, with largely undefined
implications for human health. Here we compared the susceptibility of commensal and …