Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

Rationale: Traditional treatments for leukemia fail to address stem cell drug resistance
characterized by epigenetic mediators such as histone lysine-specific demethylase 4 …

Aberrant Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling
is implicated in the pathogenesis of acute myeloid leukemia (AML), a highly heterogeneous …

Accurate orchestration of gene expression is critical for the process of normal
hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic
aberrations in oncogenes, cytogenetic abnormalities, and an aberrant epigenetic landscape …

Initiation of necroptosis has been considered as a promising strategy for anticancer
therapies, especially for eradicating apoptosis-resistant malignant cells. Jujubisode B is a …