Artemisinin is an antimalarial compound derived from the plant Artemisia annua L., also
known as sweet wormwood. According to the World Health Organization, artemisinin‐based …

The hypothalamus plays a fundamental role in controlling lipid metabolism through
neuroendocrine signals. However, there are currently no available drug targets in the …

Background Despite efforts made to reduce morbidity and mortality associated with malaria,
especially in sub-Saharan Africa, malaria continues to be a public health concern that …

Mutations affect the genes that encode certain cytochromes P450 (CYP450) isoenzymes
that are responsible for metabolism of drugs. The aim of this study was to determine the …

Africa's vast genetic diversity poses challenges for optimising drug treatments in the
continent, which is exacerbated by the fact that drug discovery and development efforts have …

Introducción: Reportes previos a nivel nacional e internacional evidencian alta incidencia
de eventos adversos, alteraciones en la biodisponibilidad en sangre y bajo control durante …

There is an increased recognition of the need to identify and quantify the impact of genetic
polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of …

Abstract Background Human cytochrome P450 2B6 (CYP2B6) is fortified with the
biotransformation of the antimalarial, artemisinin combination therapy (ACT). Owing to …

Background: Inter-ethnic differences in response to medication can be explained through
population structure as observed from genetic variants affecting drug metabolism …

Various types of genetic variation exist within the human genome, ranging from single
nucleotide changes to large-scale structural alterations. In recent years, several studies …