Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-
regulated immune evasion mechanisms, we identified an evolutionarily conserved function …

Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …

SUMOylation is a post-translational modification characterized by covalent and reversible
binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different …

Proto-oncogene Akt plays essential roles in cell proliferation and tumorigenesis. Full
activation of Akt is regulated by phosphorylation, ubiquitination, and acetylation. Here we …

Haspin phosphorylates histone H3 at Thr3 (H3T3ph) during mitosis [1, 2], providing a
chromatin binding site for the chromosomal passenger complex (CPC) at centromeres to …

The Chromosomal Passenger Complex (CPC) consisting of Aurora B kinase, INCENP,
Survivin and Borealin, is essential for genomic stability by controlling multiple processes …

Ubiquitin and ubiquitin-like (Ubl) protein modifications affect protein stability, activity, and
localization, but we still lack broad understanding of the functions of Ubl modifications. We …