Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Photothermal therapy (PTT) has emerged as a promising strategy for the treatment of
tumors. However, the intrinsic self-repair mechanism of cells and the nonspecific …

Metabolic diseases, featured with dysregulated energy homeostasis, have become major
global health challenges. Patients with metabolic diseases have high probability to manifest …

Atherosclerosis is a chronic inflammatory disease of the arterial intima and is becoming the
leading cause of morbidity and mortality worldwide. There is considerable evidence that …

The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent hepatic disease
characterized as lipid accumulation, yet without any approved drug. And development of …

To study the collaboration between lipid droplets (LDs) and lysosomes, and the lipid change
in nonalcoholic fatty liver disease (NAFLD), herein two pH-triggered hydrophility-adjustable …

Background Nonalcoholic fatty liver disease (NAFLD) has become the most common
chronic liver disease worldwide, whereas there is no approved drug therapy due to its …