PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Y Su, B Zhang, R Sun, W Liu, Q Zhu, X Zhang… - Drug …, 2021 - Taylor & Francis
Biodegradable microspheres have been widely used in the field of medicine due to their
ability to deliver drug molecules of various properties through multiple pathways and their …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Glass transition temperature of PLGA particles and the influence on drug delivery applications

G Liu, K McEnnis - Polymers, 2022 - mdpi.com
Over recent decades, poly (lactic-co-glycolic acid)(PLGA) based nano-and micro-drug
delivery vehicles have been rapidly developed since PLGA was approved by the Food and …

Methods to improve the immunogenicity of plasmid DNA vaccines

D Eusébio, AR Neves, D Costa, S Biswas, G Alves… - Drug Discovery …, 2021 - Elsevier
DNA vaccines have emerged as innovative approaches that have great potential to
overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often …

Stimuli-responsive polymeric nanovaccines toward next-generation immunotherapy

L Mao, P Ma, X Luo, H Cheng, Z Wang, E Ye, XJ Loh… - ACS …, 2023 - ACS Publications
The development of nanovaccines that employ polymeric delivery carriers has garnered
substantial interest in therapeutic treatment of cancer and a variety of infectious diseases …

Recent advances in micro-and nano-scale carrier systems for controlled delivery of vaccines

EY Wang, M Sarmadi, B Ying, A Jaklenec, R Langer - Biomaterials, 2023 - Elsevier
Vaccines provide substantial safety against infectious diseases, saving millions of lives each
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …

Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing

Q Liu, Y Zhang, J Huang, Z Xu, X Li, J Yang… - Journal of …, 2022 - Springer
The colonization of bacterial pathogens is a major concern in wound infection and becoming
a public health issue. Herein, a core–shell structured Ag@ MSN (silver core embedded with …

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and …

Y Su, J Liu, S Tan, W Liu, R Wang, C Chen - Drug Delivery, 2022 - Taylor & Francis
Microspheres play an important role in controlling drug delivery and release rate accurately.
To realize the sustainable release of insoluble small-molecule drugs, a new three-phase …

Biopolymer‐based carriers for DNA vaccine design

CO Franck, L Fanslau, A Bistrovic Popov… - Angewandte Chemie …, 2021 - Wiley Online Library
Over the last 30 years, genetically engineered DNA has been tested as novel vaccination
strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis …